The Mitostream Technology

The Mitostream® Technology

The Mitostream® technology is a cellular dynamical system approach using the intracellular self-organizing dynamic organelle, the mitochondria as a readout.

WHAT IT IS WHAT IT’S NOT (ie. Mitosafe®)
  • In cell insights
    • in disease
    • in drug safety
  • Cellular dynamical system tool trained to recognize
    • Disease signatures
    • Tolerance signature
  • Cell response to desease or drug
  • Determines occurence of drug off target effects
  • Outcome = Mitochondrial behavior in the living cell
  • Mitochondrial functional tests
  • Mechanistic response to drug
  • Identification of mitochondrial liabilities

Mitostream® = In cell insight

Mitostream® is a patented cellular dynamical system technology that encompasses the whole complexity of the mitochondrial interactions within its cellular environment, measuring its resultant: The mitochondrial behavior.

It represents the simultaneous measure of HCA variables contained within four dimensions defining the mitochondrial behavior:

  • The mitochondrial motility,
  • The mitochondrial morphology,
  • The mitochondrial reticular network organization and
  • The mitochondrial permeability.

We analyze dynamic and static images of mitochondria in live cells allowing for the characterization of disease state or of dose-response to a tested drug, either a chemical or a biological.

Validating drugs targeting multiple neurodegenerative disease etiology

Our scientists have characterized specific mitochondrial behavior patterns in normal and disease states (patents pending) and propose the qualification of disease-modifying properties of your compounds in vitro in a HCA format.

We have validated a Huntington’s disease model and are looking for partnerships in the validation of an Alzheimer’s disease model and of a muscular dystrophy model using human primary tissue.