Mitostream® Technology

The Mitostream® technology is a cellular dynamical system approach using the intracellular self-organizing dynamic organelle, the mitochondria as a readout.

Mitostream® represents a break-through innovation using the dynamical properties of the mitochondrial reticular network as a biological system

Mitostream® is a patented cellular dynamical system technology that encompasses the whole complexity of the mitochondrial interactions within its cellular environment, measuring its resultant: The mitochondrial behavior.

It represents the simultaneous measure of HCA variables contained within four dimensions defining the mitochondrial behavior:

• The mitochondrial motility,
• The mitochondrial morphology,
• The mitochondrial reticular network organization and
• The mitochondrial permeability.

We analyze dynamic and static images of mitochondria in live cells allowing for the characterization of disease state or of dose-response to a tested drug, either a chemical or a biological.

Mitostream® technology describes and quantifies the cellular response to your drug. Its applications span:

• Cellesis Toxicity profiling: Anticipate clinical tolerance at the pre-clinical stage
  Organ toxicity specific signatures
• Select range: Mitostream® secondary screening models using patient-derived cells for Huntington’s disease (HD-Select) and Alzheimer’s disease (AD-Select).
• Custom development of Select signatures from your own patient cohort.

Advantages

• HCA analysis
• High predictivity, sensitivity and specificity in toxicity assessment compared to existing predictive toxicity solutions
• Correlation with clinical tolerance industrially validated through DSEC
• Innovative patient-derived models for identification of disease-modifying capabilities in neurodegenerative diseases
• SAR and rank-ordering of compounds
• Low compound
• High added-value
• Cost-effective